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No precise dose adjustment recommended when tofacitinib coadministered with strong CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with both average CYP3A4 and potent CYP2C19 inhibitors .crizotinib increases levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction may very well